Brain and Nervous System
Blood Sugar Levels
Thyroid and Adrenal Function
Reasons for Increased Demand
Regular supplementation with alpha lipoic acid may lead to biotin deficiency.
Too much pantothenic acid (vitamin B5) may lead to biotin deficiency as it competes with biotin for intestinal and cellular uptake (because of similarities in the structure).
Lack of probiotic bacteria in intestines since bacteria are capable of producing biotin.
Consuming raw egg white. Avidin, a protein found in egg white, can lead to biotin deficiency as it binds biotin. This can be prevented by backing or boiling eggs.
Athletes and individuals very physically active may need biotin supplementation because they are most likely to experience a deficit.
Refined diet, sugar, stimulants (especially alcohol and smoking), antibiotics and some medications. Anticonvulsants inhibit biotin absorption in the small intestine or increase its urinary excretion. Low consumption of good nutritional sources of biotin, especially leafy green vegetables such as kale, spinach and Swiss chard.
Biotin deficiency is common in pregnant women, because excretion levels of this vitamin are higher. Pregnant women are advised to supplement biotin (at least 500 mcg per day).
Interactions With Medications
Possible Overdosing Side Effects
Getting too much biotin leads to deficiency of pantothenic acid (vitamin B5) as both are absorbed from the intestines via the same receptors. For example, pantothenic acid regulates the barrier function of the surface layer on skin. Therefore, a deficiency of pantothenic acid (through excess of biotin) may lead to skin problems such as acne flares and increased risk of developing cystic acne on the chin and jawline. Symptoms usually disappear a few weeks after biotin supplementation is stopped. Doses lower than 2500 mcg per day and drinking plenty of water while using biotin supplements should reduce the risk of developing cystic acne. Since high strength biotin supplements (probably over 2500mg per day) may lead to the deficiency of pantothenic acid supplementation with vitamin B5 is recommended to prevent its deficiency.
Taking high doses of biotin in early pregnancy may probably increase the risk of miscarriage, although the reasoning behind this is not clear. However, pregnant women are advised to consult a medical professional before taking high doses of biotin.
Forms of Biotin